I'm a lefty and I've shot one plenty of times, no real drama the spent cartridge is hardly noticeable and is no danger what so ever, the only thing I will say is we spend years trying to get better at hunting/shooting so why opt for something that could potentially provide a distraction however small that is
I went for a Benelli SBE left handed and it's a great gun. (Avoid Hatsans "the bitter taste of poor quality remains much longer than the sweet after taste of of a bargain has worn off")
ATB