I would never use it again stronghold or advocate sorts mange out , in past had 5 dogs with mange tuck 3 month to shift me an pal got dogs right then thay got again got rid then got again so used a lot of ivermactin to get rid of was a lot going about at time some people lost there pets to mange vets could not shift it , so did loads of reading up on ivermactin on dogs , collie type dogs can kill them an any other dogs can give health conditions as dog get older bad breathing a cough that don't go and knocks time of there life span