Every pup I have had that had a litter were different, but I would be giving at least a month after the pups were off her, my dad used to drum it into me a month, but a week for every pup over the four weeks, so if a litter of eight, eight weeks befpre serious work again....when I was young I had a bitch called Bes, this was the best all round lurcher bitch Ive ever had or seen, she had a litter, and I took no notice of my dad and began working her too early, she ran like a bag of shit..I had old lurchermens words ringing in my head, "bitches never run properly again after a litter of pups" I