I've got to agree with the stalker, have you considered the 243, it is probably the most versatile of all the common calibres. Great for fox, great for roe, and good for reds if the shot placement is good. The round is fast, easily reloaded and a good variety of bullet weight is available.
The only reason I mention reds and roe, is that if you have the rifle to shoot them, you never know what opportunities you may take up!
Out of the 3 calibres you mention for fox, the 22-250 is the only one I have any experience of for that quarry and it is devastating.