i've shot plenty large reds with no issues, i had a 6.5x55 but sold it due to needing cash, and the .243 was my primary gun for long range foxing, etc..
i loved the two calibres...
but seeing as i had no trouble droping deer at distance ..... the .243 stayed......
Ability simple as, if you don't have the ability, larger calibres can only get you so far..... A poor shot WITH any calibre is still a poor shot...
the larger calibre's are just that little bit MORE forgiving...
Snap.