I think you should invest in a cage, they are obviously taking the p*ss out of your mrs, my girls are fine and will let me know when they need to go out by crying now, I've only had 1 accident in the last week!
if you got a cage, then your mrs would find it easier and it would stop them peeing and chewing up stuff,
keep them in the cage while sleeping, bring them out to feed then put them straight outside after they have eaten, leave them out for 30 mins (even though they will cry, leave them out) then bring them back in have a play/learn session for about 45 mins then put them out ag