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Lost Generation

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Posts posted by Lost Generation

  6. Welders (people)

    in General Talk

    Posted

    57 minutes ago, Chid said:

    Right you people who weld as a job not a hobby .. mig welding vertically do you work upwards or downwards with the torch and reason why ..thanks 

    @Balaur think it's you who welds .. that's why I've tagged you 

    Start at the bottom and work up

  8. The EU vaccine crisis explained in one sentence

    in General Talk

    Posted

    7 hours ago, sandymere said:

    The vaccine is a UK success, because the government upped its orders due to pressure from the medical establishment and then let the NHS handle it rather than private backhanders to mates as with the track and trace fiasco, just goes to show how brilliant the NHS is?. Alas we aren't  out of the woods yet and its a terrible shame we had to lose so many lives up to this point.

    Image may contain: text that says "Island(s)? Yes Population? Area? (km2) Yes 126,300,000 66,600,000 377,915 242,495 Peope/km2? 334 Actual fucking distance to China? Total Deaths due to Covid-19? 275 810km 5,158 7775km 100,162 Never let the Tories forget just how badly they handled the Covid-19 pandemic"

     

    Labour run Wales hasn't done any better

    • Like 4

  9. to have the corvid jab or not

    in General Talk

    Posted

    Here's some food for MaxSnowflake and the rest of the trolls:

    How Oxford scientists developed a Covid-19 vaccine in record time

    Experts involved in the inoculation race explain how the jab was developed

    14 JAN 2021

    Tonia Thomas, vaccine knowledge project manager at the University of Oxford and Rachel Colin-Jones, visiting academic at Oxford University’s Centre for Clinical Vaccinology and Tropical Medicine, on how the first vaccine developed in the UK was produced.

    The pandemic is only a year old, but we already have multiple vaccines available to fight Covid-19 – including the vaccine developed by the team we’re part of at the University of Oxford.

    With our partner AstraZeneca, we have submitted both interim efficacy data and safety data for the vaccine to regulators across the world for independent scrutiny and approval. So far the vaccine has been approved for emergency use in the UK, India, Morocco, Argentina and El Salvador.

    As well as being great news for getting us back to normal, this represents a phenomenal scientific achievement. Typically, developing a vaccine takes decades – but we have several available for Covid-19 after just 12 months. Here’s how we managed this for the Oxford vaccine.

    A head-start on development

    Our vaccine works by delivering the genetic sequence of the SARS-CoV-2 spike protein to the body’s cells (the spike proteins are the distinctive structures that “crown” the coronavirus’s surface).

    The body’s cells read this genetic code and start producing copies of the spike protein, and the immune system then mounts a response against these proteins and remembers them. This means that if SARS-CoV-2 later enters the body, its spike proteins will immediately flag it to the immune system for destruction.

    This may sound complicated, but when the pandemic arrived, we had a head start, as we had already developed a delivery method – or “platform” – for our vaccine and had been testing it for other diseases for almost ten years. Known as the ChAdOx1 viral vector technology, this platform was created by modifying a harmless adenovirus that causes the common cold in chimpanzees.

    ChAdOx1 was chosen as it can generate a strong immune response and is not a replicating virus, so cannot cause an infection. It had already been used safely in thousands of subjects in clinical trials of vaccines for other diseases including Middle Eastern respiratory syndrome (Mers), which is caused by another type of coronavirus.

    Our ongoing research into ChAdOx1 was part of preparing for “Disease X”, one of eight diseases prioritised for research by the World Health Organization (WHO) due to the risk they pose to public health. Covid-19 has since been added to this list.

    Disease X is a placeholder name that highlights that the next serious epidemic could be caused by a pathogen as yet unknown to scientists, which is what happened with the coronavirus.

    Having an already developed platform ready meant that testing of the vaccine could begin quickly. University of Oxford

    Once researchers in China had mapped the genetic sequence of the coronavirus, we were able to quickly produce our Covid-19 vaccine by combining the ChAdOx1 vector with the genetic sequence of the SARS-CoV-2 spike protein.

    The preparation for Disease X ultimately allowed our research team to move straight into testing our vaccine in animals in early 2020, and then to combine the data from these tests with data we had already gathered in previous trials using ChAdOx1, to show that what we were developing worked.

    Making human trials more efficient

    With good data from our animal studies, we were ready to move onto clinical trials – essentially a series of tests to show that a treatment is safe and effective in humans.

    Vaccine trials are typically split into three phases. Phase 1 assesses the safety of a vaccine and how well it is tolerated, as well as the immune response. Phase 2 involves testing on a larger, more diverse group of people and is used to identify the optimal dose and schedule.

    Phase 3 then aims to test the safety and efficacy of a vaccine in a large group of people, often in multiple locations. This is usually assessed by monitoring how many cases of the disease are seen in a group that gets the vaccine versus a group that doesn’t.

    Ordinarily, the different trial phases are run separately, often with time between them for preparing protocols and funding applications, then seeking ethical and regulatory approvals. But for our vaccine, we undertook combined phase 1 and 2 and phase 2 and 3 trials to speed up the development process.

    This doesn’t mean that any of the required steps were missed out, but rather that we could launch the next stage of the trial as soon as we had collected enough data from the previous phase and had it reviewed by the independent Data Safety Monitoring Board.

    Moving quickly but safely

    Some people have questioned the speed of vaccine development during the pandemic. However, the Oxford Covid-19 vaccine trial – which is still ongoing – is undergoing the same intense scrutiny as other vaccine trials. Interim analysis has shown that the vaccine is safe and effective, but the final stages of its phase 3 trial are still being completed. 

    Throughout, all participants are being closely monitored, and a report is made about anyone who has a medically significant illness or is hospitalised, for whatever cause, even a broken leg. If any of these events is thought to be possibly related to the vaccine, an independent review takes place to carefully assess the medical information.

    While this happens, vaccinations are paused. They’re then restarted once the review is complete and it is considered safe to continue.

    All told, the vaccine will have been tested on almost five times as many volunteers as is usually required for licensing a vaccine. By the end of the trials we’re running, 24,000 people will have taken part in four countries and another 30,000 in trials run by our partners.

    Testing in different populations is crucial, as any vaccine developed for Covid-19 is likely to be deployed to a large number of people worldwide.

    Tonia Thomas, vaccine knowledge project manager at the University of Oxford, and Rachel Colin-Jones, visiting academic at Oxford University’s Centre for Clinical Vaccinology and Tropical Medicine.

    This article is republished from The Conversation under a Creative Commons license. Read the original article.

  10. to have the corvid jab or not

    in General Talk

    Posted

    2 hours ago, Greyman said:

    With vaccines that have undergone years of trials for diseases that have a much higher fatality rate than 0,2% wtf is so hard for all you super intelligent vax fans to grasp, ??

    There's a good recent study from UCL which estimates the case fatality rate for Covid-19 in developed countries at 1.15% which if the disease were left unchecked would amount to at least 690,000 deaths in a population of 60 million although with the UK's ageing population probably rather more than that, plus however many hundreds of thousands of people crippled with long-Covid. Is that what you want?

    • Like 1

  11. to have the corvid jab or not

    in General Talk

    Posted

    1 hour ago, maxhardcore said:

    The information sources say it’s not killing kids 

    SO WHY Vaccinate them ?

    None of the vaccines are licenced for use in children yet and there are no plans to vaccinate kids. I know that  vaccine companies are planning trials in children but as far as I am aware none are up and running yet and they will take quite a few months to complete & analyse.  Some children have got very ill and died from Covid but the best reason for vaccinating children would be to help achieve herd immunity by eliminating a large pool of infection which can be transmitted to others who are potentially more vulnerable.  We vaccinate children and adults against a lot of diseases for exactly this reason.

     

  12. to have the corvid jab or not

    in General Talk

    Posted

    On 10/01/2021 at 09:36, thefensarefarbutistillgo said:

    Well it’s common sense that the masks that everyone wears don’t work for an airborne virus it even says that on the box they come in ?, first of all they are suppose to be worn to protect other people rather than yourself but I think a lot of people wear them thinking it protects them, which is up to them if it makes them feel safer, also if your in a supermarket, shop ect do people think that a mask makes your breath disappear ?  It just gets pushed out around the top , bottom, sides and straight through it. The fact is that when your in a supermarket everything you breathe out is getting put into that atmosphere wether you have got a mask on or not 

    If you want a review of the evidence around mask wearing see:  https://youtu.be/IEvZhX3hQAw  Masks worn correctly reduce the mask wearer's risk of infection by about 54% and also help to protect others if the mask wearer is infected. Critically, if you do still get infected despite wearing a mask, the mask should reduce the dose of the virus you get. There is a dose-response effect with the virus, the larger dose of virus you are exposed to, the more likley it is that you will become seriously ill, so wearing a mask could mean the difference between mild illness and severe illness. 

    • Like 3

  13. to have the corvid jab or not

    in General Talk

    Posted

    1 hour ago, maxhardcore said:

    But why should free citizens be forced into something  that has a very low kill rate ?

    And that low kill rate is probably half as low as we all know the figures are being altered in respect they putting any death they can get away with down to Covid to boost the death rate .

    My neighbour just allowed out today after a positive test ‘ said he’s had worse light colds never mind flu ‘lost his sense of taste that was it .

    His Mrs and two kids who he lives with never got this Covid ?

    his bro and father never got it or his sister or her kid ect 

     

    2 more mates had it and they got their 92 year old great aunt tested as they had been helping her re house work eft

    She tested pos but did not even feel ill in any way shape or form all the way thru her supposed Covid 

    Where are all the winter colds and flu cases disappearing too ?

     

     

    1,325 new Covid deaths today. No-one is being forced into anything, no-one will be compelled to take the vaccine against their will. If you prefer to take the risk of a miserable death, slowly drowning in your own lung secretions or the risk of being left with wrecked lungs and brain rather than take a completely safe vaccination then that is up to you, although I do have some objections to the the impact your decision may have on NHS resources and the fact that you may spread the infection to others.  Use the link to the calculator I have posted and work out your own risks. 

    Most people with Covid seem to be at low risk of spreading it even within their own households, but a minority people are highly infectious and can become superspreaders if they dont take sensible precautions. At the moment there is no easy way to identify among the infected who is a high risk spreader and who isn't. Covid is a new illness, we don't know much about it yet and particularly we don't really understand if there are going to be long-term health consequences such as increased cancer risk  or increased risk of severe auto-immune reactions (like encephalitis lethargica which followed on from the 1918/1919 H1N1 Spanish Flu)  to Covid infection in those who have had mild or asymptomatic disease, just as we dont yet know the long-term outcomes of the lung, heart, brain and multi-system damage from long-Covid.  If they knew a little more about viral infections and their sequalae, I think that most people would be rather concerned more about these things than they seem to be at the moment. I have lost a family member to Covid and I also have two close friends who are struggling to cope with the severe impact of long-Covid months after their acute infection resolved and are unable to work full-time becuase of this. I also lost a family member in the first wave of Covid

     

     

     

    • Like 1

  14. to have the corvid jab or not

    in General Talk

    Posted

    4 minutes ago, Balaur said:

    Presumably if the SA variant proves similar enough to be covered by current vaccines travel arrangements and compulsory vaccination will presumably alter to suit once vulnerable are vaccinated.....

    It looks from early evidence that the current vaccines protect against the South African variant. No-one is talking about compulsory vaccination and I can't that ever being acceptable in this country

  15. to have the corvid jab or not

    in General Talk

    Posted

    3 minutes ago, Greyman said:

    So why do we need a vaccine against a virus with a 99.8 % recovery rate that 1 in 5 infected don’t even know they have it and why are we being told our hospitals are bursting at the seems when quite clearly they are not, if you don’t want suspicions stop lying about things it’s quite simple and anyone with a brain can see there is more to this than we are being told ??? So please forgive us who wish to approach with a little more caution as it’s still just about a free country and we do have a right to say no thanks  ?

     

    3 minutes ago, Greyman said:

    So why do we need a vaccine against a virus with a 99.8 % recovery rate that 1 in 5 infected don’t even know they have it and why are we being told our hospitals are bursting at the seems when quite clearly they are not, if you don’t want suspicions stop lying about things it’s quite simple and anyone with a brain can see there is more to this than we are being told ??? So please forgive us who wish to approach with a little more caution as it’s still just about a free country and we do have a right to say no thanks  ?

     Risk from Covid is individual, if you follow the link I gave earlier: https://www.qcovid.org/Home/AcademicLicence?licencedUrl=%2FPatientInformation%2FPatientInformation  you will be able to calculate your own personal risk. I am setting out the science as I know it. Remember also that this is a new infection with unknown sequalae, I have fieinds with long Covid who are pretty much incapacitated  by it and we have no idea whether they will recover or not. The reason for the mass vaccination programme is to protect those most at risk, and to sop teh NHS collapsing under the weight of sickness. You may feel invulnerable, but you could be directly responsible for the death of others by spreading the virus.

    • Like 2

  16. to have the corvid jab or not

    in General Talk

    Posted

    5 minutes ago, maxhardcore said:

    What about the unknown long term risks of any of the above vax ?

    For those actually getting the vax or their yet unborn future children ?

    The only likley risks beyond normal injection reactions (sore arm, temperature etc) are immediate an risk of anaphylaxis which is why you are required to wait around for a few minutes after the injection. The main components of the Oxford vaccine (minus the SARS-CoV2 spike protein) have been used for more than a decade in early phase clinical trials for a range of conditions (Malaria, TB, MERS etc etc) with no long-term effects detected. What you need to think about is balancing the pretty well characterised risks of these vaccines against the known and unknown risks of Covid, including long-covid. We have now vaccinated about 1.5 million people with no deaths comapred to 78,000+ Covid deaths & many tens of thousangds of people crippled with long-Covid with none of us knowiing what the long-term sequalae of infection with SARS-CoV2 may be.  The mechanism of action of tehse vaccines make long-term effects seem pretty unlikely.  The recommendation in pregnancy now is to weigh potential vaccine risks against the risk to the mother and child from Covid. The UKOSS surveillnace system is being updated to follow outcomes of pregnant women who are vaccinated against Covid

    • Like 1

  17. to have the corvid jab or not

    in General Talk

    Posted

    On 06/01/2021 at 19:39, South hams hunter said:

    Don't forget death numbers are fake but the covid jab killed someone in Portugal

    Really? The Oxford/Astra Zenecca jab has been trialed in the UK, USA, Brazil & South Africa. The Pfizer jab has been trialled in the USA, Germany, Turkey, South Africa & Brazil and the Moderna jab which was approved today has only been trailled in the USA.  None of these vaccines has been trialled in Portugal so there can't have been been any deaths on study in Portugal. The remarkable thing about these vaccines is actually how safe they are when you think that even common over the counter drugs like Aspirin kill somewhere between the low hundreds to low thousands of individuals in this country each year.  

    If you want to calculate your personal risk of dying from or being hospitalised with Covid then the calculator here: https://www.qcovid.org/Home/AcademicLicence?licencedUrl=%2FPatientInformation%2FPatientInformation  should be of interest. What you need to think about additionally, is the significant risk of being crippled, perhaps permanently by long-covid and the risk of infecting others around you and possibly being responsible for their deaths. The calculator obviously also can't take account of individual genetic differences which affect response to infection. 

  18. to have the corvid jab or not

    in General Talk

    Posted

    3 hours ago, socks said:

    I’m not sticking something into my body that hasn’t had a long term test. The government had to agree with the developers of these vaccines that they would be immune to prosecution or law suites in the future. That in itself tells me that they are not sure of long term effects. 
    I’m fit and healthy and only 52. I hardly ever get a cold or flue so I see no reason to have a Vaccine. 

    The Oxford Covid vaccine was an adaptation of the MERS vaccine which was in phase one trials in Saudi Arabia when the pandemic hit. Essentially the same basic vaccine (same viral vector etc)  has been used in early phase trials in Oxford and elsewhere for various conditions including malaria for more more than a decade with no significant ill effects seen. Oxford are just opening a big phase 3 malaria trial in Africa now using the same basic vaccine but seeded with malaria proteins developed through years of trials using this vaccine rather than the SARS-CoV-2 spike protein put into the Covid vaccine. Seasonal flu vaccines given to tens of millions each year are produced each spring/summer for the coming winter and get less testing that the Oxford vaccine and other Covid vaccines have had. All the parties who have run vaccine trials have to have appropriate insurance as a legal requirement both to run the trials and to sell commercial pharmaceutical products when approved.  

    What you also need to think about is that while the vaccines are newish, so is the virus, humans haven't had SARS-CoV-2 before and its long-term effects are unknown. The risk of death for a healthy 18 year old girl is low,  but risk of death rises sharply with age, male gender, obesity, BME ethnicity & a whole raft of underlying health problems. Interestingly, this new UK varient of the vaccine seems less benign to young people and more young people are getting seriously ill and admitted to hospital with this new strain. In addition to the risk of death something like 30-40% of people who have at least a moderately severe case of Covid seem to develop long-term health problems, in many cases quite severe long-term problems  ('long-Covid') and given that it is a new illness, no-one has any idea what the long-term outcome will be for these people.  

    No-one is going to be forced to take the vaccine but as the pool of the vaccinated grows, increasingly a higher proprotion of cases will come from the unvaccinated and those too stupid to take sensible precautions to protect themselves and thair family and friends from infection so in a few months time, there should be a selective viral culling of the stupid, the gullible and the paranoid and we will all be better off with fewer of these people in our midst.

  21. Name the species

    in Wildlife and General Photography

    Posted

    They were all as pictured above. talking to a few people now, I suspect they are immature and I hope to go back to the spot in the next couple of days to try and find out what they look like when mature becuase at the moment they are a real puzzler . If I can find the spot, I will post pictures here of the fungi when mature

    • Like 1
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